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Mass Photometry: An Easy Way to Determine Protein Oligomerization and Heterogeneity
Mass photometry (MP) is a rapid, label-free technique for assessing protein oligomerization and heterogeneity using minimal sample volumes (10 µL at 10–50 nM). It detects light scattering from individual proteins, generating histograms revealing different oligomeric states. MP is particularly useful for early-stage quality checks before complex studies like cryo-EM or crystallography.
